Postdoctoral Position in Circular RNA Biology and Inflammatory Bowel Disease

Postdoctoral Position in Circular RNA Biology and Inflammatory Bowel Disease

Employer

INEM Institute

Location

Paris, Ile-de-France (FR)

Salary

35,964/year gross (net ~ 29,724), Inserm postdoc scale, plus benefits (health insurance, pension, transport subsidy).

Closing date

29 Dec 2026

Discipline

Life Science

Job Type

Postdoctoral

Employment - Hours

Full time

Duration

Fixed term

Qualification

PhD

Sector

Academia

Job Details

Position Overview

The Arbibe Laboratory at Institut Necker Enfants Malades is seeking a motivated Postdoctoral Research Fellow with strong hands-on expertise in circular RNA (circRNA) biology, to investigate how circRNAs together with other non-canonical RNA species such as double-stranded RNAs (dsRNAs) contribute to intestinal inflammation and epithelial repair in inflammatory bowel disease (IBD).

The position is part of an ANR-funded consortium project, will start in February 2027, and is funded for 3 years.

Research Focus

The successful candidate will investigate RNA regulatory mechanisms in intestinal inflammation, with particular emphasis on:

• Circular RNA (circRNA) biogenesis, functional characterization, and regenerative potential in the intestinal epithelium
• RNA regulatory mechanisms underlying intestinal inflammation and epithelial repair in IBD
• Double-stranded RNA (dsRNA) biology in the gut epithelium
• Molecular and cellular approaches combined with intestinal organoids, mouse models, and human IBD samples

Why Join the Arbibe Laboratory at INEM?

Our laboratory is part of the Institut Necker Enfants Malades (INEM, Inserm U1151/CNRS UMR8253), located on the Necker-Enfants Malades hospital campus in central Paris, with a strong interest in intestinal inflammation and RNA biology (Mata-Garrido et al., Nature Communications, 2022, https://doi.org/10.1038/s41467-022-34556-3).

The INEM Institute provides a collaborative environment bringing together fundamental and clinical research, with access to state-of-the-art core facilities in genomics, imaging, flow cytometry, animal experimentation and organoid culture.

The postdoctoral researcher will interact closely with scientists and clinicians at INEM and with the broader Paris biomedical research community, including Paris Cit University, Institut Pasteur and Sorbonne Universit .

More information about our team and research: https://www.institut-necker-enfants-malades.fr/node/2902

Qualifications

Applicants should have a PhD or equivalent degree in RNA biology, molecular biology, cell biology, immunology or a related discipline. Strong expertise in RNA biology is essential for this position.

Eligibility requirement: candidates must have defended their PhD within the last 2 years at the time of application.

Expertise

Hands-on expertise in circular RNA (circRNA) biology validation (divergent RT-PCR, RNase R resistance, back-splice junction sequencing) and functional characterization is mandatory for this position.

The following additional skills would be an advantage:

• RIP-seq, CLIP/eCLIP-seq, or related RNA protein/RNA interaction mapping approaches
• Epitranscriptomic approaches
• Experience with mouse models and/or intestinal organoid culture

How to Apply

Interested applicants should submit:

• A curriculum vitae
• A brief statement describing previous research experience
• Contact information for two to three references

Applications should be sent to: laurence.arbibe@inserm.fr